1aoi

About this Structure
1AOI is a 10 chains structure of sequences from Xenopus laevis. The July 2000 RCSB PDB Molecule of the Month feature on Nucleosome by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_7. Full crystallographic information is available from OCA.



The nucleosome core particle contains two copies of each histone protein ( H2A, H2B, H3, H4 ) and 146 basepairs (bp) of superhelical DNA wrapped around this histone octamer. It represents the first order of DNA packaging in the nucleus and as such is the principal structure that determines DNA accessibility.

For a more detailed exploration of this structure, see Nucleosome Structure at the Online Macromolecular Museum.

Reference
Page seeded by OCA on Wed Feb 18 02:45:37 2009